Leber Hereditary Optic Neuropathy: Do Folate Pathway Gene Alterations Influence the Expression of Mitochondrial DNA Mutation?
"nBackground: Leber hereditary optic neuropathy (LHON) is an inherited form of bilateral optic atrophy leading to the loss of central vision. The primary cause of vision loss dv1433-010 is mutation in the mitochondrial DNA (mtDNA), however, unknown secon­dary genetic and/or epigenetic risk factors are suggested to influence i